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Transition from Remodulin Understanding the transition to Orenitram

Transitioning from Remodulin (treprostinil)
Injection to Orenitram

Sometimes doctors make the decision to transition certain PAH patients from a pump form of prostacyclin medicine to a pill form. Transitioning to Orenitram is not possible for everyone. However, if your PAH is responding well to pump therapy and you have been on a stable dose for some time, your healthcare team may consider you a good candidate. Here are reasons why some consider making the transition:

Oral medication

Instead of a pump, you swallow tablets a few times a day*

No infusion site pain

Orenitram can help you avoid infusion site pain or reactions like swelling, redness, or rash

Treatment needs change

Since PAH is a progressive disease, your needs may change. You may even have to return to Remodulin at some point. Regular testing will tell your doctor what kind of treatment is right for you

*Orenitram may also be taken 2 times a day (every 12 hours). Tablet strength may be increased depending on how well you tolerate treatment. The maximum daily dose for Orenitram is 120 mg.

What to expect during the transition from Remodulin to Orenitram

Transition may happen at home or at the hospital, depending on what your healthcare team thinks is best. They will gradually increase your dose of Orenitram while decreasing your dose of pump therapy until you're just taking Orenitram. This adjustment period is called titration.

Transitioning from a PAH pump to a pillTransitioning from a PAH pump to a pill

You've successfully transitioned from pump therapy to Orenitram when you're only taking Orenitram at your most effective dose.

In a clinical study All 33 patients on stable doses of Remodulin successfully transitioned from pump therapy to Orenitram within 4 weeks—and most did so in less than 1 week.†

†During the study, 2 patients stopped taking Orenitram early and transitioned back to pump therapy.

Stick with it!

During titration, your body is still getting used to the medicine, and you will likely experience side effects, such as headaches, nausea, vomiting, and diarrhea. Side effects may be different from those you experienced with pump therapy. Remember that side effects may get better with time as you continue to adjust to Orenitram.

Jenny's Experience with Orenitram

Watch Jenny discuss how she and her doctor decided to transition to Orenitram and developed a dosing plan that aligns with her treatment goals.

View Transcript

Discuss with your HCP to see if you are a good candidate.

You need to take Orenitram with food. What kind of food counts too.

Learn about food and Orenitram

Important Safety 
Information for Orenitram

Who should not take Orenitram?

Do not take Orenitram if you have severe liver problems.

What should I tell my healthcare provider before taking Orenitram?

Tell your healthcare provider:

What is Orenitram?

Orenitram is a prescription medicine used to treat pulmonary arterial hypertension (PAH) which is high blood pressure in the arteries of your lungs. Orenitram can help slow down the progression of your disease and improve your ability to exercise. It is not known if Orenitram is safe and effective in children.

Important Safety Information for Orenitram

Who should not take Orenitram?

Do not take Orenitram if you have severe liver problems.

What should I tell my healthcare provider before taking Orenitram?

Tell your healthcare provider:

  • If you have liver problems or diverticulosis.
  • If you are pregnant, breastfeeding, and/or plan to become pregnant or breastfeed. It is not known if Orenitram will harm your unborn baby or if Orenitram passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby during treatment with Orenitram.
  • About all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Orenitram and other medicines may affect each other causing side effects. Do not start any new medicine until you check with your healthcare provider. Especially tell your healthcare provider if you take another medicine that contains treprostinil, such as Remodulin® or Tyvaso®.

What is Orenitram?

Orenitram is a prescription medicine used to treat pulmonary arterial hypertension (PAH) which is high blood pressure in the arteries of your lungs. Orenitram can help slow down the progression of your disease and improve your ability to exercise. It is not known if Orenitram is safe and effective in children.

How should I take Orenitram?

  • Do not change your dose or suddenly stop taking Orenitram without first talking to your healthcare provider.
  • Orenitram is usually taken 3 times a day (about every 8 hours) or 2 times a day (about every 12 hours). Your healthcare provider will tell you how often you should take Orenitram. If you have side effects, your healthcare provider may tell you to change your dose or when you take Orenitram. Take Orenitram with food.
  • Swallow Orenitram tablets whole. Do not split, chew, crush, or break your Orenitram tablets. Do not take Orenitram tablets that are damaged or broken. If Orenitram tablets are not taken whole, they may release too much medicine at one time. This can lead to side effects.
  • If you miss your dose of Orenitram, take the missed dose as soon as possible with food.
  • If you miss 2 or more doses of Orenitram, call your healthcare provider to see if you need to change your dose.
  • If you take too much Orenitram, call your healthcare provider or go to the nearest hospital emergency room right away.
  • You may see the tablet shell in your stools (bowel movements). This is usually normal. The tablet shell is not digested. If you have diverticulosis, the tablet shell may get stuck in a blind pouch or diverticulum in your intestine.

What are the possible side effects of Orenitram?

Orenitram can cause serious side effects, including worsening of PAH symptoms.

  • Stopping Orenitram suddenly may cause worsening of your PAH symptoms. Do not change your dose or suddenly stop taking Orenitram without first talking to your healthcare provider.
  • The most common side effects of Orenitram include headache, diarrhea, nausea, vomiting, flushing, and pain in arms, legs, and jaw. These are not all of the possible side effects of Orenitram. Tell your healthcare provider if you have any side effect that bothers you or does not go away.
  • Call your healthcare provider for medical advice about side effects. You may report side effects to the FDA at www.fda.gov/MedWatch or call 1‑800‑FDA‑1088.

What is Orenitram?

Orenitram is a prescription medicine used to treat pulmonary arterial hypertension (PAH) which is high blood pressure in the arteries of your lungs. Orenitram can help slow down the progression of your disease and improve your ability to exercise. It is not known if Orenitram is safe and effective in children.

The risk information provided here is not comprehensive. To learn more about Orenitram, talk with your healthcare provider.

Please see Full Prescribing Information and Patient Information at www.orenitram.com or call Customer Service at 1‑877‑UNITHER (1‑877‑864‑8437).

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