Managing Side Effects Understanding expected side effects with Orenitram
Common side effects
The most common side effects with Orenitram include headache, diarrhea, nausea, vomiting, flushing, and pain in the arms, legs, and jaw.
What to know about side effects with Orenitram
- Side effects are a normal part of taking Orenitram, especially at first
- They may get better with time as you continue increasing your dose of Orenitram
- Taking Orenitram at the same time you eat or 15 minutes after may help reduce side effects. Learn more about food and Orenitram

[Tracking side effects], I was able to kind of see the patterns of what I was doing wrong or what I was doing right. I've learned that I do have to eat as much as I can so that I don't have many side effects.
- Orenitram Patient
Individual experiences may vary.

IT PAYS TO BE
PROACTIVE
Side effects are a reality—but that's not the whole story. Write down your experience. Talk to a doctor. And know that feeling better is possible if you stick with it.
Tips for managing expected side effects
The more you communicate with your healthcare team about side effects, the better.
That way, they can suggest some ways to help. United Therapeutics does not provide medical advice.
Your healthcare provider will work with you to develop a plan to manage side effects.

Headaches
Over‑the‑counter treatments such as acetaminophen or ibuprofen for headaches

Nausea & vomiting
Various anti‑nausea and anti‑vomiting medications

Diarrhea
Adding fiber to your diet or taking anti‑diarrhea medication
Staying focused on your treatment goals
Because of the way Orenitram works, you'll probably experience side effects before any benefits. It can be tough. But staying on track means you have a chance to see real improvements in your PAH symptoms. Try these things to help keep your goal in focus:
Remember that you are not alone
For over 10 years, Orenitram
has helped many patients do
more to control their PAH.Lean on your community
Be open with friends and family about what you're going through—and don't be afraid to reach out for support. Online communities can be great too.
Know what you want
What is PAH getting in the way of?
Write a list of hopes and goals
for life with Orenitram.Keep in touch with your healthcare team
It is important to talk to your healthcare provider about side effects you experience so you can get advice on how to help manage them.

Resources
Download the side effect management guide
Get more information on expected side effects and management strategies.
Download NowLearn about savings and support
Cost savings & support
