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Managing Side Effects Understanding expected side effects with Orenitram

Common side effects

The most common side effects with Orenitram include headache, diarrhea, nausea, vomiting, flushing, and pain in the arms, legs, and jaw.

What to know about side effects with Orenitram

  • Side effects are a normal part of taking Orenitram, especially at first
  • They may get better with time as you continue increasing your dose of Orenitram
  • Taking Orenitram at the same time you eat or 15 minutes after may help reduce side effects. Learn more about food and Orenitram
Orenitram Patient
[Tracking side effects], I was able to kind of see the patterns of what I was doing wrong or what I was doing right. I've learned that I do have to eat as much as I can so that I don't have many side effects.

- Orenitram Patient

Individual experiences may vary.

note book

IT PAYS TO BE 
PROACTIVE

Side effects are a reality—but that's not the whole story. Write down your experience. Talk to a doctor. And know that feeling better is possible if you stick with it.

Tips for managing expected side effects

The more you communicate with your healthcare team about side effects, the better. 
That way, they can suggest some ways to help. United Therapeutics does not provide medical advice.
 Your healthcare provider will work with you to develop a plan to manage side effects.

Headache

Headaches

Over‑the‑counter treatments such as acetaminophen or ibuprofen for headaches

Headache

Nausea & vomiting

Various anti‑nausea and anti‑vomiting medications

Headache

Diarrhea

Adding fiber to your diet or taking anti‑diarrhea medication

Luisa's experience with side effects

Learn how Luisa works with her healthcare team to balance titration and side effects.

View Transcript

Staying focused on your treatment goals

Because of the way Orenitram works, you'll probably experience side effects before any benefits. It can be tough. But staying on track means you have a chance to see real improvements in your PAH symptoms. Try these things to help keep your goal in focus:

  • Ten Years

    Remember that you are not alone

    For over 10 years, Orenitram
    has helped many patients do
    more to control their PAH.

  • Community

    Lean on your community

    Be open with friends and family about what you're going through—and don't be afraid to reach out for support. Online communities can be great too.

  • check list

    Know what you want

    What is PAH getting in the way of?
    Write a list of hopes and goals
    for life with Orenitram.

  • care team

    Keep in touch with your healthcare team

    It is important to talk to your healthcare provider about side effects you experience so you can get advice on how to help manage them.

Guide to help managing side effects with Orenitram

Resources

Download the side effect management guide

Get more information on expected side effects and management strategies.

Download Now

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Important Safety 
Information for Orenitram

Who should not take Orenitram?

Do not take Orenitram if you have severe liver problems.

What should I tell my healthcare provider before taking Orenitram?

Tell your healthcare provider:

What is Orenitram?

Orenitram is a prescription medicine used to treat pulmonary arterial hypertension (PAH) which is high blood pressure in the arteries of your lungs. Orenitram can help slow down the progression of your disease and improve your ability to exercise. It is not known if Orenitram is safe and effective in children.

Important Safety Information for Orenitram

Who should not take Orenitram?

Do not take Orenitram if you have severe liver problems.

What should I tell my healthcare provider before taking Orenitram?

Tell your healthcare provider:

  • If you have liver problems or diverticulosis.
  • If you are pregnant, breastfeeding, and/or plan to become pregnant or breastfeed. It is not known if Orenitram will harm your unborn baby or if Orenitram passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby during treatment with Orenitram.
  • About all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Orenitram and other medicines may affect each other causing side effects. Do not start any new medicine until you check with your healthcare provider. Especially tell your healthcare provider if you take another medicine that contains treprostinil, such as Remodulin® or Tyvaso®.

What is Orenitram?

Orenitram is a prescription medicine used to treat pulmonary arterial hypertension (PAH) which is high blood pressure in the arteries of your lungs. Orenitram can help slow down the progression of your disease and improve your ability to exercise. It is not known if Orenitram is safe and effective in children.

How should I take Orenitram?

  • Do not change your dose or suddenly stop taking Orenitram without first talking to your healthcare provider.
  • Orenitram is usually taken 3 times a day (about every 8 hours) or 2 times a day (about every 12 hours). Your healthcare provider will tell you how often you should take Orenitram. If you have side effects, your healthcare provider may tell you to change your dose or when you take Orenitram. Take Orenitram with food.
  • Swallow Orenitram tablets whole. Do not split, chew, crush, or break your Orenitram tablets. Do not take Orenitram tablets that are damaged or broken. If Orenitram tablets are not taken whole, they may release too much medicine at one time. This can lead to side effects.
  • If you miss your dose of Orenitram, take the missed dose as soon as possible with food.
  • If you miss 2 or more doses of Orenitram, call your healthcare provider to see if you need to change your dose.
  • If you take too much Orenitram, call your healthcare provider or go to the nearest hospital emergency room right away.
  • You may see the tablet shell in your stools (bowel movements). This is usually normal. The tablet shell is not digested. If you have diverticulosis, the tablet shell may get stuck in a blind pouch or diverticulum in your intestine.

What are the possible side effects of Orenitram?

Orenitram can cause serious side effects, including worsening of PAH symptoms.

  • Stopping Orenitram suddenly may cause worsening of your PAH symptoms. Do not change your dose or suddenly stop taking Orenitram without first talking to your healthcare provider.
  • The most common side effects of Orenitram include headache, diarrhea, nausea, vomiting, flushing, and pain in arms, legs, and jaw. These are not all of the possible side effects of Orenitram. Tell your healthcare provider if you have any side effect that bothers you or does not go away.
  • Call your healthcare provider for medical advice about side effects. You may report side effects to the FDA at www.fda.gov/MedWatch or call 1‑800‑FDA‑1088.

What is Orenitram?

Orenitram is a prescription medicine used to treat pulmonary arterial hypertension (PAH) which is high blood pressure in the arteries of your lungs. Orenitram can help slow down the progression of your disease and improve your ability to exercise. It is not known if Orenitram is safe and effective in children.

The risk information provided here is not comprehensive. To learn more about Orenitram, talk with your healthcare provider.

Please see Full Prescribing Information and Patient Information at www.orenitram.com or call Customer Service at 1‑877‑UNITHER (1‑877‑864‑8437).

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