Skip to main content

Titration Kit Designed for a simple, confident start

Why is titration important?

Titration is all about finding the most effective dose for you,* also known as your "target dose." That's why it's important to stay committed to your treatment. You may not get the most benefit from Orenitram until you reach your target dose and will likely experience side effects during this time. The Orenitram Titration Kit is designed to make the process simple.†

The Orenitram Titration Kit

ALL-IN-ONE KIT to help simplify the first 3 months of taking Orenitram and put you on the path toward reaching your target dose

ORGANIZED DOSES so you know your exact dose every morning, afternoon, and evening

3 monthly kits

Each monthly kit includes:

  • Support based on where you are during titration
  • A simple outline of that month's Orenitram doses
Orenitram weekly boxes

4 weekly boxes per month

Each Weekly Box includes:

  • How to take Orenitram
  • What to do if you miss a dose
Orenitram Titration Kit

7 daily packs per week

Each Daily Pack includes:

  • Your exact morning, afternoon, and evening doses of Orenitram
  • Tools to help ensure you're staying on track

*The maximum daily dose for Orenitram is 120 mg.

†Patients new to treatment who are starting Orenitram on a 3-a-day dosing schedule are eligible for the Titration Kit.

Learn more about your Orenitram Titration Kit

View Transcript
Orenitram Titration Kit Patient Start Guide

Resources

Download the Orenitram Titration Kit guide

Read more about the Orenitram Titration Kit.

Download Now

Frequently Asked Questions

Titration is the process of slowly increasing your dose of Orenitram over time until you find the most effective dose for you. You will likely experience side effects during this time. The maximum daily dose is 120 mg.

Starting a new treatment can be challenging, but the Titration Kit is designed to make treatment with Orenitram simpler. Instead of receiving your medication in bottles, your first 3 months of Orenitram will be organized each day in packs.

The Titration Kit contains helpful information about dosing, simple instructions, and reminders to know your exact morning, afternoon, and evening doses of Orenitram.

If you've started on Orenitram and you miss a dose, take the dose as soon as possible with food. If you miss 2 or more doses, call your healthcare provider for guidance.

Is your doctor considering moving you from a pump to pill?

Learn about transitioning to Orenitram

Important Safety 
Information for Orenitram

Who should not take Orenitram?

Do not take Orenitram if you have severe liver problems.

What should I tell my healthcare provider before taking Orenitram?

Tell your healthcare provider:

What is Orenitram?

Orenitram is a prescription medicine used to treat pulmonary arterial hypertension (PAH) which is high blood pressure in the arteries of your lungs. Orenitram can help slow down the progression of your disease and improve your ability to exercise. It is not known if Orenitram is safe and effective in children.

Important Safety Information for Orenitram

Who should not take Orenitram?

Do not take Orenitram if you have severe liver problems.

What should I tell my healthcare provider before taking Orenitram?

Tell your healthcare provider:

  • If you have liver problems or diverticulosis.
  • If you are pregnant, breastfeeding, and/or plan to become pregnant or breastfeed. It is not known if Orenitram will harm your unborn baby or if Orenitram passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby during treatment with Orenitram.
  • About all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Orenitram and other medicines may affect each other causing side effects. Do not start any new medicine until you check with your healthcare provider. Especially tell your healthcare provider if you take another medicine that contains treprostinil, such as Remodulin® or Tyvaso®.

What is Orenitram?

Orenitram is a prescription medicine used to treat pulmonary arterial hypertension (PAH) which is high blood pressure in the arteries of your lungs. Orenitram can help slow down the progression of your disease and improve your ability to exercise. It is not known if Orenitram is safe and effective in children.

How should I take Orenitram?

  • Do not change your dose or suddenly stop taking Orenitram without first talking to your healthcare provider.
  • Orenitram is usually taken 3 times a day (about every 8 hours) or 2 times a day (about every 12 hours). Your healthcare provider will tell you how often you should take Orenitram. If you have side effects, your healthcare provider may tell you to change your dose or when you take Orenitram. Take Orenitram with food.
  • Swallow Orenitram tablets whole. Do not split, chew, crush, or break your Orenitram tablets. Do not take Orenitram tablets that are damaged or broken. If Orenitram tablets are not taken whole, they may release too much medicine at one time. This can lead to side effects.
  • If you miss your dose of Orenitram, take the missed dose as soon as possible with food.
  • If you miss 2 or more doses of Orenitram, call your healthcare provider to see if you need to change your dose.
  • If you take too much Orenitram, call your healthcare provider or go to the nearest hospital emergency room right away.
  • You may see the tablet shell in your stools (bowel movements). This is usually normal. The tablet shell is not digested. If you have diverticulosis, the tablet shell may get stuck in a blind pouch or diverticulum in your intestine.

What are the possible side effects of Orenitram?

Orenitram can cause serious side effects, including worsening of PAH symptoms.

  • Stopping Orenitram suddenly may cause worsening of your PAH symptoms. Do not change your dose or suddenly stop taking Orenitram without first talking to your healthcare provider.
  • The most common side effects of Orenitram include headache, diarrhea, nausea, vomiting, flushing, and pain in arms, legs, and jaw. These are not all of the possible side effects of Orenitram. Tell your healthcare provider if you have any side effect that bothers you or does not go away.
  • Call your healthcare provider for medical advice about side effects. You may report side effects to the FDA at www.fda.gov/MedWatch or call 1‑800‑FDA‑1088.

What is Orenitram?

Orenitram is a prescription medicine used to treat pulmonary arterial hypertension (PAH) which is high blood pressure in the arteries of your lungs. Orenitram can help slow down the progression of your disease and improve your ability to exercise. It is not known if Orenitram is safe and effective in children.

The risk information provided here is not comprehensive. To learn more about Orenitram, talk with your healthcare provider.

Please see Full Prescribing Information and Patient Information at www.orenitram.com or call Customer Service at 1‑877‑UNITHER (1‑877‑864‑8437).

OREISIconOCT19