Skip to main content

How to Take Orenitram Making Orenitram a part of your routine

A guide to taking Orenitram

Like other medicines you may be taking, Orenitram is an oral tablet.
You take it with food, usually 3 times daily (every 8 hours).*

Taking Orenitram with food helps the body absorb the medicine and may help reduce side effects, such as vomiting and nausea. Talk to your healthcare team about food choices that may work best for you and get more tips here.

*Orenitram may also be taken 2 times a day (every 12 hours). Tablet strength may be increased depending on how well you tolerate treatment. The maximum daily dose is 120 mg.

Example schedule

Breakfast icon
Breakfast
7 AM
6 AM
8 HOURS
Afternoon snack icon
Afternoon snack
3 PM
2 PM
8 HOURS
Bedtime snack icon
Bedtime snack
11 PM
10 PM
[My advice is to] be very patient with yourself and your body until it kind of adjusts to the new form of medication going into the body.

- Orenitram Patient

Individual experiences may vary.

Finding your dose

When you start Orenitram, your healthcare team will work with you to gradually increase your dose—a process called titration.

During this time, your body is still getting used to the medicine, and you will likely experience side effects. Remember that side effects may get better with time as you continue increasing your dose of Orenitram. And, there may be ways to manage expected side effects.

Personalized dosing

Five different tablet strengths make it easier for your healthcare provider to adjust your dose.

Since PAH is a progressive disease, your treatment needs may change over time. Your healthcare provider can continue to increase or change your dose to meet your needs. That way, you may be able to stay with Orenitram long term to help control your PAH. The maximum daily dose is 120 mg.

Orenitram PAH tablet strengths

Not shown at actual size.

Tips for staying on track

Starting a new medication can feel like a lot. But there are steps you can take to help keep things on track. Remember, sticking with Orenitram means you have a chance to see real improvement.

Snack icon

You don’t have to take Orenitram with a full meal—a snack is fine

Calendar icon

To avoid missing a dose, try adding alerts to your calendar or smartphone alarm

Medicine icon

If you’ve started on Orenitram and you miss a dose, take a dose as soon as possible with food. If you miss 2 or more doses, call your healthcare provider for guidance

Planner icon

Try using the meal planner to plan out how Orenitram can fit into your day

Discover the kit designed to simplify your dosing plan

Titration Kit

Important Safety 
Information for Orenitram

Who should not take Orenitram?

Do not take Orenitram if you have severe liver problems.

What should I tell my healthcare provider before taking Orenitram?

Tell your healthcare provider:

What is Orenitram?

Orenitram is a prescription medicine used to treat pulmonary arterial hypertension (PAH) which is high blood pressure in the arteries of your lungs. Orenitram can help slow down the progression of your disease and improve your ability to exercise. It is not known if Orenitram is safe and effective in children.

Important Safety Information for Orenitram

Who should not take Orenitram?

Do not take Orenitram if you have severe liver problems.

What should I tell my healthcare provider before taking Orenitram?

Tell your healthcare provider:

  • If you have liver problems or diverticulosis.
  • If you are pregnant, breastfeeding, and/or plan to become pregnant or breastfeed. It is not known if Orenitram will harm your unborn baby or if Orenitram passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby during treatment with Orenitram.
  • About all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Orenitram and other medicines may affect each other causing side effects. Do not start any new medicine until you check with your healthcare provider. Especially tell your healthcare provider if you take another medicine that contains treprostinil, such as Remodulin® or Tyvaso®.

What is Orenitram?

Orenitram is a prescription medicine used to treat pulmonary arterial hypertension (PAH) which is high blood pressure in the arteries of your lungs. Orenitram can help slow down the progression of your disease and improve your ability to exercise. It is not known if Orenitram is safe and effective in children.

How should I take Orenitram?

  • Do not change your dose or suddenly stop taking Orenitram without first talking to your healthcare provider.
  • Orenitram is usually taken 3 times a day (about every 8 hours) or 2 times a day (about every 12 hours). Your healthcare provider will tell you how often you should take Orenitram. If you have side effects, your healthcare provider may tell you to change your dose or when you take Orenitram. Take Orenitram with food.
  • Swallow Orenitram tablets whole. Do not split, chew, crush, or break your Orenitram tablets. Do not take Orenitram tablets that are damaged or broken. If Orenitram tablets are not taken whole, they may release too much medicine at one time. This can lead to side effects.
  • If you miss your dose of Orenitram, take the missed dose as soon as possible with food.
  • If you miss 2 or more doses of Orenitram, call your healthcare provider to see if you need to change your dose.
  • If you take too much Orenitram, call your healthcare provider or go to the nearest hospital emergency room right away.
  • You may see the tablet shell in your stools (bowel movements). This is usually normal. The tablet shell is not digested. If you have diverticulosis, the tablet shell may get stuck in a blind pouch or diverticulum in your intestine.

What are the possible side effects of Orenitram?

Orenitram can cause serious side effects, including worsening of PAH symptoms.

  • Stopping Orenitram suddenly may cause worsening of your PAH symptoms. Do not change your dose or suddenly stop taking Orenitram without first talking to your healthcare provider.
  • The most common side effects of Orenitram include headache, diarrhea, nausea, vomiting, flushing, and pain in arms, legs, and jaw. These are not all of the possible side effects of Orenitram. Tell your healthcare provider if you have any side effect that bothers you or does not go away.
  • Call your healthcare provider for medical advice about side effects. You may report side effects to the FDA at www.fda.gov/MedWatch or call 1‑800‑FDA‑1088.

What is Orenitram?

Orenitram is a prescription medicine used to treat pulmonary arterial hypertension (PAH) which is high blood pressure in the arteries of your lungs. Orenitram can help slow down the progression of your disease and improve your ability to exercise. It is not known if Orenitram is safe and effective in children.

The risk information provided here is not comprehensive. To learn more about Orenitram, talk with your healthcare provider.

Please see Full Prescribing Information and Patient Information at www.orenitram.com or call Customer Service at 1‑877‑UNITHER (1‑877‑864‑8437).

OREISIconOCT19