What is Orenitram?
Orenitram is the only FDA-approved prostacyclin analogue in a tablet to treat PAH and has been shown to improve exercise ability (or walking distance). In a large study, patients on Orenitram showed improvement in their 6 minute walk distance compared to patients on placebo (a pill without active ingredients).* With Orenitram, there is information available for your healthcare team about how patients stable on pump therapy (treprostinil) transitioned to oral therapy. It is not known if Orenitram is safe and effective in children under 18 years of age.
*A 12 week study of 349 patients with PAH not currently receiving any other PAH therapy
Similar medicine as in a pump, but in a tablet
Orenitram is the only pill that gives you the same type of medicine (active ingredient) that is available in pump therapy. In a small study,† patients in the hospital stable on pump therapy (treprostinil) successfully switched to Orenitram while maintaining their 6-minute walk distance and right heart catheterization results.
†An open-label, uncontrolled (no placebo) study of 33 hospitalized patients with PAH.
Orenitram may help you reach your goals
Because Orenitram is an oral option, you may enjoy activities like being in the pool or taking a bath. Taking Orenitram may improve your ability to exercise. This means you could see improvement in physical activities, such as walking to the mailbox.
If you have been diagnosed recently or have had PAH for some time, Orenitram may be right for you.
Doctor Discussion Guide
The Doctor Discussion Guide provides questions and discussion topics to help guide the conversation with your healthcare provider to determine if Orenitram may fit into your treatment plan.Download Now
How does Orenitram work?
If you have PAH, your body may not produce enough of a natural substance called prostacyclin. Orenitram mimics some of the effects of the natural prostacyclin that your body lacks. This can help open up blood vessels, making it easier for your heart to pump blood through your lungs.
Dosing that fits your scheduleYour doctor will prescribe Orenitram to be taken either twice or 3 times each day. With 4 different dose strengths available, your healthcare provider is able to prescribe Orenitram according to your treatment needs. Learn more about taking Orenitram.
You may experience side effects when taking Orenitram
• Headache • Nausea • Diarrhea • Flushing
There are other possible side effects of Orenitram. Tell your healthcare provider about any side effects that bother you, get worse over time, or do not go away.
Call your healthcare provider for medical advice about side effects. You may report side effects to the FDA at www.fda.gov/MedWatch or call 1-800-FDA-1088.
Daily Treatment Diary
The Daily Treatment Diary can help you keep track of how you are feeling each day of treatment. You can also write down important notes that you may want to discuss with your healthcare provider.Download Now
Support during your treatment
In addition to support from your healthcare provider, Orenitram patients can receive support from Specialty Pharmacies and may be eligible for various programs offered by United Therapeutics, the company that makes Orenitram.
Explore support available, from in-home training to telephone support, as well as educational resources or connecting with a PEER Mentor.Learn More